GLIOBLASTOMA STEM CELLS DELIVER ABCB4 TRANSCRIBED BY ATF3 VIA EXOSOMES CONFERRING GLIOBLASTOMA RESISTANCE TO TEMOZOLOMIDE

Glioblastoma stem cells deliver ABCB4 transcribed by ATF3 via exosomes conferring glioblastoma resistance to temozolomide

Hobby Paint Abstract Glioblastoma stem cells (GSCs) play a key role in glioblastoma (GBM) resistance to temozolomide (TMZ) chemotherapy.With the increase in research on the tumour microenvironment, exosomes secreted by GSCs have become a new focus in GBM research.However, the molecular mechanism by which GSCs affect drug resistance in GBM cells via

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Comparative transcriptomics from intestinal cells of permissive and non-permissive hosts during Ancylostoma ceylanicum infection reveals unique signatures of protection and host specificity

Soil-transmitted nematodes (STNs) place a tremendous burden on health and economics worldwide with an estimate of at least 1.5 billion people, or 24% of the population, being infected with at least 1 STN globally.Children and pregnant women carry the heavier Mountaineering - Homme - Vetements - Manteau pathological burden, and disease caused by the

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Environmental and ecological water requirements of a river system : a case study of the Haihe-Luanhe River system

In order to reduce the environmental and ecological problems induced by water resources management and use, this paper proposes a concept of environmenta water requirement.It is defined as the minimum water amount to be consumed by the natural water bodies to Equestrian Riding Gloves conserve its environmental and ecological functions.Based on the

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Intelligent Hybrid Taguchi-Genetic Algorithm for Multi-Criteria Optimization of Shaft Alignment in Marine Vessels

An intelligent Equestrian Riding Gloves hybrid Taguchi-genetic algorithm (IHTGA) is used to optimize bearing offsets and shaft alignment in a marine vessel propulsion system.The objectives are to minimize normal shaft stress and shear force.The constraints are permissible reaction force, bearing stress, shear force, and bending moment in the shaft

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